Objective To explore the real experience of mild cognitive impairment patients with memory decline,and to provide references for clinical staff to carry out follow-up medical nursing intervention. Methods Using objective sampling method,9 patients with mild cognitive impairment in the Department of Neurology of a tertiary hospital in Beijing from May to June 2021 were selected as the research subjects for semi-structured interviews,and the data were analyzed by Colaizzi 7-step analysis method in phenomenological research. Results The real experience of memory loss in patients with mild cognitive impairment can be summarized into 3 themes:disease perception of memory loss(attitude of contempt and denial,introspection of reflection and traceability,and change of interactive relationship);emotional experience of memory decline(generation of anxiety and fear,reduction of self-efficacy,formation of self enlightening attitude,expectation of facing the future);coping strategies for memory loss (lifestyle coping,physical and mental activity coping,future planning coping). Conclusion We should strengthen the popularization of medical knowledge about memory loss in patients with mild cognitive impairment,pay attention to their emotional needs,give psychological counseling,family support and social support,and carry out personalized cognitive intervention to promote their cognitive improvement and return to family and society.